Tlhatlhobo ea Sesamol

Sesamol ke semela se holiloeng bakeng sa oli ea Sesame ka lipeo tsa sona. E fumaneha habonolo libakeng tse chesang le tse chesang tse mongobo Asia, Amerika Boroa le Afrika. E tšoana hantle le limela tse ling ho kenyelletsoa le meroho le soya. Li-Sesamol tse tsoang peo ho lumeloa hore li na le oli e ngata haholo. Oli ea Sesame ke mohloli o ruileng oa liprotheine, li-antioxidants le livithamini.  Sesamol phofo e sebelisoa haholo ho moriana oa Ayurveda ho phekola mathata a fapaneng a bophelo bo botle ntle le litlamorao tse mpe

 

Sesamol ke eng

Sesamol ke motsoako oa tlhaho o hlahang ka tlhaho o fumanehang ho oli e sebelisitsoeng ea sesame le peo e halikiloeng ea sesame.

Sesame (Sesamum indicum) ke semela sa selemo le selemo sa Pedaliaceae lelapa. Limela tsa sesame li tsoa Afrika Bochabela le India empa kajeno li lengoa linaheng tse ngata lefatšeng. E 'nile ea lengoa ho tloha mehleng ea khale bakeng sa oli ea eona le peo e jeoang. Sesame e boetse e tsejoa e le benne, gingelly, hape e tsejoa e le 'Mofumahali oa Lioli tsa oli'.

 

Mechanism ea Sesamol

Mechine ea Sesamol e fapaneng e tlatsana le litlamorao tsa eona tsa antioxidant, anti-prolifative, anti-inflammatory, anti-apoptotic. Mochine oa Sesamol o kenyelletsa;

 

i. E thibela lipid peroxidation

Sesamol e thibela lipid oxidation ho lisele tse kang sebete le pelo ka ho felisa li-radicals tsa mahala tse hlahisang lipid peroxidation.

 

Ii. Ho ntlafatsa ts'ebetso ea phetoho e kholo

Sesamol komponeng e na le bokhoni ba ho tlosa li-radicals tsa mahala joalo ka hydroxyl le peroxynitrite radicals tse bakang khatello ea mali.

 

Iii. Phallo ea li-enzyme tsa antioxidative

Sesamol e ntlafatsa haholo mesebetsi ea li-enzyme tsa bohlokoa tsa antioxidant tse kang superoxide dismutase, catalase, le glutathione peroxidase.

 

Iv. Inihibits lisele tse nang le tšoaetso

Sesamol e khothaletsa tlhahiso ea li-cytokine tsa nitric oxide le cytokin tse haelloang, ha e ntse e hatella polelo ea nalane ea nitric oxide hape e khothaletsa Nrf2, e leng tsela ea antioxidant. Ho feta moo, Sesamol e khona ho thibela tsela ea MAPK le NF-κB le ho theola tlhahiso ea mefuta ea oksijene e sebetsang, eo ka nako e tšoanang e fokotsa karabelo ea ts'oaetso.
Sesamol tlatsana

v. Fokotsa maemo a nitrites

Sesamol e sebetsa joaloka Anti-inflammatory moemeli ka ho fokotsa boemo ba li-nitrites, tseo hangata e leng babuelli ba methapo ea mafu.

 

re. Kholo ea seleng e tšoaroa ka methati e fapaneng ea sele

Sesamol e bontšitsoe hore e liehisa kholo ea lisele maemong a S a thusang haholo ho fokotsa kholo ea mofets'e.

 

VII. E lebisa apoptosis

Sesamol e ka ts'oants'a apoptosis ka ho thibela methapo ea masapo ea mokokotlo, ho eketsa oksijene e sebetsang, le ka litsela tse kenang le tse tsoang ho tsona.

Mechini e meng e sebelisoang ke Sesamol e kenyelletsa; ts'ireletso ea DNA khahlano le ts'enyo, ts'ebetso ea litsela tsa cell cell, le thibelo ea ts'ebetso ea sele.

 

Mochine oa metabolism oa Sesamol ho vivo

Sesamol e ngata e tšeloa 'mele' meleng ka mor'a hore e kenngoe ka har'a pina ea ka mpeng. E qhalakantsoe ka mefuta e kopaneng ea Sesamol glucuronide le sesaminol sulphate ho sebete. Tse ling kaofela lia kopanngoa ebe li tsamaisoa ho ea ho lisele tsa 'mele, ebe karolo e phahameng ea tsona e isoa bokong, lipong le matšoafong.

Phuputsong e entsoeng ka likhoto, kalafo ea Sesamol e fumanoe e baka litekanyetso tse fokotsehileng tsa Sesamol ka serum le lipalo tse phahameng tsa metabolite ea sulphate le glucuronide.

 

Melemo ea Sesamol

Ho tloha mehleng ea khale ho fihlela lefats'e la kajeno, oli ea sesame e sebelisitsoe ho pheha, bophelo bo botle ba moriri ka lebaka la ho ba teng ha antioxidant, Sesamol le melemo ea bophelo bo botle e amanang le eona ho kenyelletsa;

 

(1) Surname ea antioxidant

Li-antioxidants ke likhomphutha tse thibelang kapa tse liehang ho senya lisele tse hlahisoang ke li-radicals tsa mahala. Li-radicals tsa mahala hangata li lebisa khatellong ea oxidative e amanang le ho baka ho ruruha le mafu a mang. Sesamol antioxidant e fumaneha ka oli ea sesame mme e bapala karolo ea bohlokoa ho sireng liseleng hore li se ke tsa senyeha ha oxidative.

Phuputsong ea likhoto tse 30 tsa banna ba Wilstar albino, Isoproterenol (sehlopha ISO) e sebelisitsoe ho etsa tšenyo ea oxidative myocardial. Oli ea sesame e fuoang molomo ka 5 le 10 ml / kg boima ba 'mele e bonts'itse matla a sireletsang a Sesamol ka ho fokotsa ntho e sebetsang ea thiobarbituric acid (TBARS) le ho ntlafatsa ts'ebetso e matlafatsang ea ho thibela tšoaetso.

 

(2) Lithibela-mafu

Bacteria ke likokoana-hloko tse ka fumanoang kae kapa kae lefatšeng. Li ka ba molemo kapa tsa ba kotsi ho lebisang ho tsitsipaneng mafu a makhopho, tšoaetso ea pampiri ea urine hara mafu a mang. Sesamol e na le litlamorao tse khahlanong le baktheria tse e etsang hore e be karolo ea bohlokoa.

Boithuto bo bonts'itse ts'ebetso ea antimicrobial ea sesamol compound khahlano le likokoana-hloko tse 'maloa tsa baktheria le fungal.

 

(3) Khahlano le tšoaetso

Ho ruruha ke ts'ebetso e thusang 'mele ea ho itšireletsa khahlanong le lintho tse kantle ho ts'oaetso, likotsi le chefo tse thusang pholiso. Le ha ho le joalo, ho ruruha ho sa feleng ho etsahalang ha mmele o lula o le tlhokomelong ea nako e telele ho ka ba le phello e mpe 'meleng.

Tlatsetso ea Sesamol e tsejoa ho ba le thepa e ka khahlano le ho ruruha.

Phuputsong e entsoeng ka likhoto, tlatsetso ea Sesamol ho tlalehiloe ho fokotsa systemic lipopolysaccharide (LPS) -situsitse ho ruruha ha matšoafo ka thibelo ea karabelo ea ts'oaetso ea alveolar macrophage ho litoeba. Sesamol e lebisitse ho fokotseha ha likotsi tsa matšoafo le edema.

 

(4) Phello ea antitumor

Makhopho ke bongata ba lisele tse hlahisoang ke kholo ea lisele tse sa tloaelehang (lisele tse holang ebe 'mele ha o hloke' me o fapana le lisele tse tloaelehileng tse sa shoeng). Le ha e se lihlahala tsohle tse nang le mofetše, ho loketse ho li tlosa moo ho khonehang.

Bafuputsi ba 'maloa ba tlalehile hore Sesamol o na le litlamorao tse ling tse khahlanong le mofetše. Sesamol e bontšitsoe ho kenya apoptosis liseleng tse fapaneng tsa mofets'e.

Boithuto ba mahlale bo bontšitse hore Sesamol e lebisa ho kenngeng ha apoptosis liseleng tsa mofetše oa lefu la setho ka ho sitisa bokhoni ba membrane, ka hona, ho hloka taolo ea mitochondrial.

 

(5) Phallo ea mali e tlase

Khatello ea mali e phahameng ke boemo bo tloaelehileng bo ka bakang mathata a kang lefu la pelo (CVD), lefu la liphio le stroke.

Bopaki bo hlahisitsoeng kopanong ea selemo le selemo ea Mokhatlo oa pelo oa Amerika bo bontšitse hore Sesamol e na le bokhoni ba ho theola khatello ea mali. Boithuto bona bo kenyeletsa basali ba 133 le banna ba 195 ba nang le khatello ea maikutlo. Kamora ho kenngoa tlatsetso ea Sesamol ka matsatsi a mashome a tšeletseng, khatello ea bona ea mali e ile ea oela ka har'a maemo a tloaelehileng.

Sesamol tlatsana

(6) Ho tlosa theknoloji ea mahala ea mahala

Li-radicals tsa mahala ke liathomo tse sa tsitsang tse bakang tšenyo ea lisele tse lebisang botsofaling le ho kula.

Sesamol e fumanoe e na le thepa ea anti-oxidant ka ho fokotsa lisebelisoa tsa mahala tse kang radroxyl radicals, hydrogen peroxide, nitric oxide le superoxide.

 

(7) Khahlano le radiation

Radiation ke ntho e 'ngoe le e' ngoe moo matla a tsoang ho 'mele o le mong o fetelang setsing se itseng ho fihlela' mele o mong bakeng sa ho monya. Tšireletso ea mahlaseli a kotsi e thibela monyetla oa litlamorao tse kotsi tse khethollang kahoo ho fokotsa monyetla oa litlamorao tse kang litlamorao tsa lefutso le mofetše.

Ho ithuta ka litlamorao tsa Ho tsoa Sesamol ka radiation, gamma-radiation ea litekanyetso tse fapaneng e ne e lebisitsoe ho li-lymphocyte pele li phekoloa ka Sesamol extract. Ho fumanoe hore kalafo ea pele ea Sesamol e na le ts'ireletso e makatsang khahlano le ts'enyo ea cellular e hlahisoang ke radiation ea gamma ho li-lymphocyte tsa batho. Sesamol e bonts'a litlamorao tsa ts'ireletso ea radio tse thibelang ts'enyo ea DNA. Ntle le moo, Sesamol e ntlafatsa tokiso ea DNA kamora γ -radiation

 

(8) Phello ea antimutagenic

Mutagenicity e bolela mofuta oa phetoho ea nako e sa lekanyetsoang ho sebopeho sa DNA le sebopeho sa eona. Mutagenecity hangata e baka phetoho e sa rateheng e lebisang ho mafu a kang anemia-cell anemia. Sesamol e bonts'itse ts'ebetso ea anti-mutagenic mefuteng ea oksijene e hlahisang mutagenecity.

 

(9) Matšoao a metabolism

Metabolic syndrome ke sehlopha sa maemo (a joalo ka khatello e phahameng ea mali, litekanyo tse phahameng tsa tsoekere ea mali le ho bokelloa hampe k'holeseterole maemo) a atisang ho sebetsa 'moho le ho eketsa kotsi ea mafu a pelo, lefu la tsoekere, le botena.

Ho nona haholo ke feela ho bokella mafura a mangata a mmele. Phuputsong ea morao tjena, litoeba tsa banna tse nang le botenya bo fetotsoeng li ile tsa tlatsetsoa Sesamol tlatsetso ea boima ba 100mg / kg letsatsi le letsatsi bakeng sa libeke tse 'ne. Sena se ile sa fokotseha phaello ea boima ba litoeba tsa botenya le ho fokotsa ho bokellana ha lipid bokong lisele tsa manonyeletso a adipose.

Phuputsong ea mofuta oa 60 oa batho ba nang le lefu la tsoekere ba sesame, ba sebelisitsoeng ba le bang kapa ba kopantsoe le meriana e meng ea lefu la tsoekere, ho bakile litekanyetso tsa tsoekere ea mali nakong ea matsatsi a mashome a tšeletseng.

Boithuto bo 'maloa bo fumane hore Sesamol e etsa hore ho be le tahlello ea mitochondrial membrane (mmP) mme e boetse e senya metabolism ea matla a mitochondrial. Ho feta moo, Sesamol e hatella mitophagy le mitochondrial biogeneis e khothalletsang lefu la sele ea carcinoma ka ho bokella mitochondria e nang le sekoli se eketsehileng. Lithuto li khothalelitse hore mitochondrion e na le karolo e kholo ho hepatocellular carcinoma apoptosis e leng Sesamol-induction.

 

(10) Ho hanyetsa insulin

Khanyetso ea "insulin" ke boemo boo 'mele o sa arabele insulin e lebisang boemong bo eketsehang ba insulin le tsoekere ea mali. Sena se hlahisa maemo a bophelo bo botle ba kang lefu la tsoekere la Type2, khatello e phahameng ea mali le botenya. Sesamol ho tlalehiloe hore e eketsa kutloisiso ea insulin hape le maemo a insulin.

 

(11) Lefu la Neurodegenerative

Lefu la Neurodegenerative ke polelo e kopaneng e bolelang maemo a bakang tšenyo ea methapo ea kelello bokong ba motho. Boemo bona bo kenyelletsa lefu la Alzheimer's, Lefu la Parkinson le lefu la Huntington. Mathata ana a ama mesebetsi ea 'mele ea rona joalo ka ho sisinyeha, ho hema, ho leka-lekana, ho bua le ho sebetsa ha pelo.

Patlisisong e entsoeng ke litsebi tsa methapo ea kutlo ka litoeba tse nang le tahi ea tšepe, ho ile ha fumaneha hore Sesamol e fana ka tšireletso khahlano le ho se sebetse hantle ka hepatic le khatello ea methapo ea oxidative. Ho boetse ho tlalehiloe hore Sesamol e ka sebelisoa ho phekola lefu la Huntington.

 

Sesamol le Sesamin

Sesamol le sesamin ke li-antioxidants tse matla tse fumanoang ho peo ea sesame le oli ea sesame. Ho fapana le sesamin le lignant tse ling tsa sesame tse kang sesaminolin, Sesamol e fumaneha feela ka lipalo tse fumanehang ho lipeo tsa sesame tse tala. Sena, ka hona, se hloka synthet ea Sesamol.

 

Na melemo ea Sesamol bakeng sa moriri le letlalo?

Ho na le tse ngata Moriri oa Sesamol melemo e kenyeletsang;

 

i. E khothalletsa ho hōla ha moriri

Ho silila oli ea Sesame hloohong ho matlafatsa lifate le li-follicles tsa moriri ka lebaka la litšobotsi tse phahameng tsa ho phunyeletsa. E khothaletsa kholo ea moriri ka ho ntlafatsa phallo ea mali ea letlalo la hlooho. Ho boleloa hore oli ea Sesame bakeng sa moriri e folisa tšenyo e bakiloeng ke lik'hemik'hale tse feteletseng e sebelisang mebala ea moriri kapa kalafo efe kapa efe ea moriri.

 

Ii. E thibela ho lahleheloa ke moriri

Ho lahleheloa ke moriri ho ka hlaha ka lebaka la khatello ea maikutlo kapa mafu a kang mofetše. Sesamol e sebelisitsoeng ka ho silila e fana ka phello e thobang e thusang ho fokotsa khatello ea maikutlo le ho thibela khatello ea maikutlo e amanang le khatello ea maikutlo.

Sesamol tlatsana

Iii. Ho lokisa moriri o senyehileng

Sesamol ke karolo e ntle haholo ea ho nchafatsa moriri o senyehileng ka lebaka la bokhoni ba eona ba ho kenella hare letlalong. Sena se tiisa hore bothata ba moriri bo phekoloa kahare mme ka hona ho hlaha moriri o phetseng hantle.

 

Iv. Molemo oa Sesamol bakeng sa moriri o moputsoa

Moriri o tlang pele ho moriri ke ntho eo u ke keng ua e lakatsa bakeng sa moriri oa hau. Leha ho le joalo, moriri o moputsoa o ka hlaha ka lebaka la ho se khonehe ha 'mele ho hlahisa melanin e lekaneng, khatello ea maikutlo, liphatsa tsa lefutso, ho se je hantle le tšebeliso ea lik'hemik'hale.

Tlatsetso ea Sesamol ha e sebelisoa hantle ha e thuse feela ho boloka 'mala oa tlhaho empa hape e bonts'a thepa e lefifi e thusang ho fifatsa moriri o se o ntse o le putsoa.

 

v. Liphallelo tse tsoang ho li-dandruffs

Li-dandruffs li ka hlaha ka lebaka la letlalo le omeletseng, litla-morao tsa melemo ea lihlahisoa tsa letlalo le boteng ba fungus.

Sesamol e na le lithibela-mafu tse loantšang libaktheria le li-fungus ka lebaka leo li felisang ponahalo ea litšoelesa letlalong.

Melemo ea Sesamol bakeng sa letlalo li netefalitsoe ka lithuto tse fapaneng. Tse ling tsa melemo ea letlalo la Sesamol li kenyelletsa;

 

i. Tšireletso mahlaseling a UV

Ho lumeloa hore Sesamol e fana ka lesela le sireletsang letlalong ho thusa motho ho baleha likotsi tsa mahlaseli a UV.

 

Ii. Ho fepa letlalo

Sesame oli e nang le li-antioxidants tse kang Sesamol le sesamonil li kenella ka hare ho likarolo tsa letlalo tse thusang letlalo ho nchafala 'me ka hona e be letlalo le khanyang.

 

Iii. Ho tlosa acnes

Hangata li-Acnes li hlaha ka lebaka la pores ea letlalo le koahelang le likokoana-hloko tse ling tse kotsi. Oli ea sesame e na le mafura a acid a sa e nolofalletseng hore a sebelisoe ntle le ho koala maqhubu. Ntle le moo, matla a antibacterial a Sesamol a ea hole le ho bolaea likokoana-hloko tse kotsi ke ka hona letlalo le se nang makhopho.

 

Mekhahlelo ea hajoale ea ho kopanya Sesamol ke efe?

Sesamol, e leng motsoako o moholo oa li-antioxidant mehloling e meng ea sesame, hangata e hlahisoa ho tsoa ho sesamolin ka ho halika peo ea sesame le ka ho tšela oli ea sesame.

(1) oli ea Sesame

Oli ea sesame e thehiloe haholo-holo ka peo e tala e hatelitsoeng semela sa selemo le selemo sa sesame (Letšoao la Sesamum). Sesamol synthesis ho tsoa sesame oli ke mokhoa o bonolo ka ho fetisisa. Leha ho le joalo, e theko e boima haholo bakeng sa tlhahiso ea khoebo ka lebaka la ts'ebeliso e phahameng ea solvent.

Sesamol tlatsana

(2) Piperonamine

Sesamol synthesis ea Piperonamine ka ts'ebetso ea hydrolysis ke mokhoa oa theknoloji o sebelisoang ke bahlahisi ba bang ba khoebo. Mokhoa, leha ho le joalo, o na le bofokoli ba bona kaha ba tlameha ho sebetsana le maikutlo a fapaneng. Li-pigment tse entsoeng ka pokellong ea Sesamol li ke ke tsa felisoa ka ho sesa, e leng se etsang hore e be leeme ho hola tlhahiso.

 

(3) Jasmonaldehyde

Semi-synthesis ea Jasmonaldehyde ka ts'ebetso ea hydrolysis e kopantsoeng le oxidation ke ts'ebetso e sebetsang haholo e netefatsang baetsi ba tlhahiso e ntle ea Sesamol. Ts'ebetso e kenyelletsa theknoloji ea ho tlosa litšila le li-oxidants tse ntlafatsang ho arohana ha Sesamol ho tloha sebakeng sa tlholeho. Ts'ebetso ena e fokotsa haholo menyetla ea ho hlaha hoa mahlakore, ho baka ho ts'oaroa ka mokhoa o hloekileng oa Sesamol. Boholo ba bareki ba Sesamol reka sena kristale-joaloka sesame phofo.

 

Sesamol e sebelisetsoa masimo afe hona joale?

Indasteri ea lithethefatsi-

Sesamol e sebelisitsoe haholo ho hlahiseng lithethefatsi le ts'ebeliso e amanang le eona ka lebaka la bokhoni ba eona ba ho phekola mafu a fapaneng a joaloka mathata a pelo,

 

Indasteri ea lijo-

Sesamol ke se kenyelletsang lijo se sebelisoang ho linoko, litatso tsa lijo le mebala. E ntse e sebelisoa le ho pheha e le setlhare.

Indasteri ea tlhokomelo ea batho le litlolo- Sesamol e sebelisitsoe ho dae ea moriri, mebala le oli bakeng sa bophelo bo botle ba moriri.

 

Nka fumana phofo ea sesame e ntle ka ho fetisisa?

Phofo e ntle ka ho fetisisa ea sesame e ka rekoa inthaneteng ho tsoa ho barekisi ba kentsoeng ba sesame mme ka mokhoa o makatsang theko ea sesame ha e theko e tlase ha e bapisoa le li-antioxidants tse ling tsa tlhaho. Leha sena e le antioxidant ea tlhaho nahana ka ho sheba lebitso bakeng sa tšebeliso e nepahetseng le litla-morao life tse ka bang teng tsa Sesamol tse bonts'itsoeng.

 

References
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  3. Devarajan, Sankar & Rao, M & G, Sambandam le Pugalendi, Viswanathan. (2006). Phuputso ea Pilot ea Open Label Sesame Oil e nang le lefu la tsoekere le phahameng. Tlaleho ea Lijo tsa Meriana. 9 (3). 408-12. 10.1089 / jmf.2006.9.408.
  4. Hou, Yu-Chi & Tsai, Shang-Yuan & Liu, I-Ling & Yu, Chung-Ping & Chao, Pei-Dawn. (2008). Phetoho ea Metabolic ea Sesamol le Ex Vivo Effect ho 2, 2 '-Azo-bis (2-amidinopropane) -dihydrochloride-Induced Haemolysis. Tlaleho ea chemistry ea temo le lijo. 56. 9636-40. 10.1021 / jf801453f.
  5. Majdalawieh, AF, & Mansour, ZR (2019). Sesamol, lignan e kholo ea lipeo tsa sesame (sesamum Symbum): Thepa ea anti-cancer le mekhoa ea ts'ebetso. European Journal of Pharmacology, 855, 75-89.
  6. Saleem, MT, Chetty, MC, & Kavimani, S. (2013). Putative antioxidant ea oli ea sesame ka mofuta oa khatello ea mali o tsoang likotsi tsa myocardial. Jenete ea lipatlisiso tsa lefu la pelo le pelo, 4(3), 177-181.
  7. SESAMOL (533-31-3)

 

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