Pyrroloquinoline quinone (pqq) ke eng?

Pyrroloquinoline quinone (PQQ) hape e tsejoang e le methoxatin ke phofo ea cofactor e kang Vitamin lijong tse ngata tsa semela. PQQ e boetse e hlaha ka tlhaho ka lebeseng la motho le ka har'a lisele tsa mammalian.

Le ha ho le joalo e fumaneha ka lipalo tsa motsotsoana ho seo u se jang pqq phofo e ngata tlhahiso e hlokahala bakeng sa ho fumana lipalo tse lekaneng 'meleng.

Pele PQQ e fumanoe e le coenzyme ho libaktheria tseo ts'ebetso ea eona e neng e ts'oana le ea B-Vitamin ho batho, mme e bapala karolo ho nts'etsapele kholo ea likokoana-hloko tsena.

Ho batho, e sebetsa e le ntho e senang vithamine e nang le melemo e mengata ea bophelo bo botle.

Mokhoa oa Khato

Pyrroloquinoline quinone (pqq) e bonts'a melemo e mengata ea bophelo bo botle ka mekhoa e fapaneng joalo ka taolo ea litsela tse bonts'ang maqhubu a cellular, ho lahla li-radicals tsa mahala le tšebetso ea redox.

Mekhoa ea ho sebetsa ea pqq e kenyelletsa:

• E ama tsela eo liphatsa tsa lefutso li sebetsang ka eona

Pyrroloquinoline quinone e ka ama tsela eo mefuta e fapaneng e hlahisoang ka eona, haholo-holo liphatsa tsa lefutso tse amehang ketsahalong ea mitochondria. Ts'ebetso ea eona ea antioxidant ho thoe e na le makhetlo a 100 a vithamine C.

Tlatsetso ea PQQ e bonts'itsoe ho kenya ts'ebetsong lits'oaetso tsa CREB le PGC-1a tse sebetsanang ka kotloloho le mitochondria biogeneis.

E sebetsa joalo ka antioxidant

Ts'ebetso ea anti-oxidative ea Pyrroloquinoline quinone (haholo-holo ka lebaka la matla a eona) e bakoa ke bokhoni ba eona ba ho fokotseha ho PQQH2 ka karabelo le baemeli ba fokotsa lintho tse kang cysteine, glutathione kapa nicotinamide adenine dinucleotide phosphate (NADPH).

• E thibela li-enzyme

Pyrroloquinoline quinone le eona e sitisa enzyme thioredoxin reductase 1 (TrxR1), eo ka eona e baka mesebetsi ea Nuclear factor erythroid 2 (Nrf2) e khothalletsang tlhahiso ea antioxidant.

PQQ e boetse e tsejoa ho thibela nts'etsopele ea li-quinoprotein (liprotheine tse senyang) tse lebisang bothateng ba Parkinson.

Melemo ea "quinone" ea "prinone" ea bohlokoa ka ho fetisisa

Ho na le le melemo e mengata ea pyrroloquinoline quinone ho kenyelletsa:

i. PQQ e khothalletsa ts'ebetso ea mitochondrial

Mitochondria ke li-organelles tse hlahisang matla liseleng ka sebopeho sa ATP ka ho phefumoloha ka seleng. Khafetsa li fetisetsoa litsing tsa motlakase bakeng sa sele kapa lifeme tsa matla.

Tlhahiso ea matla ke senotlolo sa bophelo bo phetseng hantle.

Ho hloka taolo ea Mitochondrial ho hokahane le mathata a 'maloa a joalo ka kholo e fokotsehileng, bofokoli ba mesifa, mathata a methapo ea methapo joaloka lefu la pelo, khatello ea maikutlo le lefu la tsoekere har'a maemo a mang a bophelo bo botle.

Pyrroloquinoline quinone e ntlafatsa ts'ebetso ea mitochondrial ka ho susumetsa tlhahiso ea lisele tse ncha tsa mitochondria (mitochondrial biogenesis). Sena se etsahala ka ts'ebetso ea CAMP e arabelang ea protheine ea 1 (CREB) le Peroxisome proliferator-activated receptor-gamma coactivator (PGC) -1alpha, litseleng tse matlafatsang mitochondrial biogenesis.

Pyrroloquinoline quinone e boetse e eketsa lintlha tsa phetisetso tse sebetsang joalo ka li-antioxidants kahare ho mitochondria ke ka hona li re sirelletsang khatello ea maikutlo.

Pqq e boetse e tsosa li-enzyme ho mitochondria e eketsang tlhahiso ea matla.

Mohlaleng oa rat, ho haella ha PQQ lijong ho tlalehiloe ho sitisa ts'ebetso ea mitochondrial.

Melemo ea pyrroloquinoline quinone

Ii. E emisa ho ruruha

Ho ruruha ho sa feleng ke motso oa mafu a mangata a kang lefu la pelo le lefu la tsoekere. Pyrroloquinoline quinone e na le thepa ea antioxidant e e thusang ho tlosa li-radicals tsa mahala ka hona li thibela ho ruruha le tšenyo ea lisele.

Lipatlisiso tse ling li bontša seo Tlatsetso ea PQQ e fella ka ho fokotseha ho makatsang ha matšoao a mangata a tšoaetso e kang nitric oxide ka matsatsi a mararo feela.

Phuputsong ea litoeba tse nang le ramatiki, ramatiki ea PQQ e tlalehiloe e fana ka ts'ireletso khahlanong le ho fokola hoa mmele ka mor'a matsatsi a 45.

Iii. E ntlafatsa bophelo bo botle ba kelello le tšebetso

Pyrroloquinoline quinone e khona ho holisa boko hape (neurogeneis) ka tlhahiso ea lintlha tse ngata tsa kholo ea methapo.

Phuputso e 'ngoe e ile ea etsa qeto ea hore tlatsetso ea pqq e susumetsa motsoako oa methapo ea methapo le li-neuron.

Pyrroloquinoline quinone e amahantsoe le mohopolo o ntlafalitsoeng le ho ithuta ka lebaka la bokhoni ba eona ba ho nchafatsa lisele tsa boko.

Phuputsong e entsoeng ka batho ba 41 ba phetseng hantle empa ba tsofetse, PQQ e laetsoeng ka 20 mg / letsatsi bakeng sa libeke tse 12 e fumanoe e le ho thibela phokotso ea ts'ebetso ea boko, haholo ka ho mamelisisa le mohopolo o lebisaneng.

Pyrroloquinoline quinone le eona e ka thusa ho thibela likotsi tsa boko.

Ka 2012, phuputso ea likhoto tse fuoeng pqq matsatsi a 3 pele ho tsoa likotsi tse mpe tsa bokong li fumane hore tlatsetso e khona ho sireletsa lisele tsa boko Khahlanong le likotsi tsena.

Iv. PQQ e ntlafatsa boroko

Pyrroloquinoline quinone (PQQ) e thusa ho ntlafatsa boleng ba hau ba boroko ka ho fokotsa nako e nkuoeng, ho eketsa nako ea boroko le ho ntlafatsa boleng ba boroko ka kakaretso.

Pyrroloquinoline quinone le eona e ka fokotsa palo ea lihormone tsa khatello (cortisol) kahare ho batho ka hona ho ntlafatsa boroko ba bona.

Phuputsong ea batho ba baholo ba 17, PQQ e fanoeng ka 20 mg / letsatsi bakeng sa libeke tse 8 e fumanoe ho ntlafatsa boleng ba boroko ho latela nako e eketsehileng ea ho robala le ho robala butle.

PQQ e ntlafatsa boroko

v. E ntlafatsa bophelo bo botle ba pelo

Bokhoni ba pyrroloquinoline quinone ho laola maemo a k'holeseterole e etsa hore e fokotse kotsi ea lefu la pelo e kang stroke.

Phuputsong ea batho ba baholo ba 29, tlatsetso ea pqq e fokotsitse haholo litekanyetso tsa cholesterol e mpe ea LDL.

Pyrroloquinoline quinone e boetse e fokotsa maemo a triglycerides a lebisang tšebetsong ea mitochondrial e ntlafalitsoeng. Phuputsong e nang le likhoto, ppq e fanoeng e fumanoe e le ho theola maemo a bona a triglyceride.

Tlatsetso ea Pqq e ka thusa ho thibela kapa ho khutlisetsa atherosulinosis (stroke). Boithuto bo bong bo bontšitse hore ppq e ka fokotsa protheine ea C-reactive le trimethylamine-N-oxide e leng matšoao a bohlokoa a bokuli bona.

re. Moemeli ea ka bang nako e telele

Pyrroloquinoline quinone e nkuoa e le ntho e sa hlokeng kholo ea vithamini, ka hona e ka thusa ho holisa kholo ea hau le kholo.

Mosebetsi oa quinone oa Pyrroloquinoline ho loantša ho ruruha, ho thibela khatello ea oxidative le ts'ehetso ea ts'ebetso ea mitochondrial e paka bokhoni ba eona ba ho lelefatsa bophelo ba motho.

PQQ e boetse e netefalitsoe ho kenya ts'ebetso lits'ebetso tse bonts'ang lisele tse iphetolang botsofe ba maqhubu.

Litlamorao tse kopaneng tsa methati ena li thusa hore PQQ e u sireletse ho botsofe ba cellular hape e matlafatse bophelo bo bolelele.

Ka mofuta oa phoofolo, tlatsetso e nang le pqq e fumanoe ho fokotsa khatello ea maikutlo le ho eketsa nako ea bophelo ba li-circworms.

VII. Tšireletso likhatellong tsa oxidative

PQQ e hokahana le liprotheine ka hona li thibela oxidation liseleng. E boetse e khona ho tlosa li-radicals tsa mahala 'meleng.

Phuputsong ea phoofolo, tlatsetso ea pqq e fumanoe ho thibela lefu la cellon le amanang le oxidative.

Ho ile ha etsoa phuputso e 'ngoe a vitro e tlaleha hore PQQ e sirelletse lisele tsa mitochondria tse ka thoko ho tsoa ts'enyo kamora khatello ea oxidative le ho tlosa radicals ea superoxide.

Phuputso e tsoelang pele ka litoeba tsa lefu la tsoekere la streptozotocin-indedu (STZ), PQQ e fanoeng ho 20 mg / kg bodyweight bakeng sa matsatsi a 15 e fumanoe e le ho fokotsa maemo a serum a lihlahisoa tsa glucose le lipid peroxidation, hape e phahamisitse mesebetsi ea li-antioxidants bokong ba panya ea lefu la tsoekere. .

Li-quinone tse ling tsa pyrroloquinoline li sebelisa 'me melemo e kenyelletsa:

Ho thibela botenya

E ntlafatsa sesole sa 'mele

E ntlafatsa kemolo

E khothalletsa ts'ebetso ea kelello le memori

E thusa ho loantša mokhathala

Boemong ba hona joale lefatšeng, litaba tse mpe ka lebaka la COVID 19 li tla nako le nako. Ntoa ea Pyrroloquinoline quinone coronavirus e ka sebelisoa. Tlatsetso ena e khahlisang e tla ntlafatsa ho itšireletsa ha hau le ho u thusa ho robala ho imolla khatello ea maikutlo.

quinone ea pyrroloquinoline e sebelisoa

Litlamorao ke life tsa pyrroloquinoline quinone (pqq)?

Ha u fumana PQQ ho tsoa mehloling ea lijo ha ho na litlamorao tse lebelletsoeng ntle le hore motho a kulisoe ke lijo tse itseng.

Lithutong tsa liphoofolo le likhoto, lefu la renal le amahanngoa le tlatsetso ea PQQ. Phuputsong e le 'ngoe e nang le litoeba, PQQ e kentseng boima ba 11-12 mg / kg boima ba mmele e tlalehiloe e baka tsitsipano ea meno.

Phuputsong e 'ngoe ea litoeba, PQQ ho 20 mg / kg bodyweight e fumanoe e baka chefo ho tishu ea renal le hepatic.

Mafu a bolaeang le 'ona a boetse a tlalehiloe ka litekanyetso tse phahameng tsa 500 mg.

Ho batho, ha ho litla-morao tse bohloko tsa pyrroloquinoline quinone tse tlalehiloeng ka litekanyetso tsa ho fihlela ho 20 mg / ka letsatsi.

Leha ho le joalo, liketsahalong tse sa tloaelehang, litla-morao tsa li-quinone tse ka bang teng li ka hlaha ka lebaka la ho sebelisa li-overdos tse ngata. Litla-morao tsena li kenyelletsa hlooho ea hlooho, mokhathala, ho otsela, hypersensitivity le ho hloka boroko.

Tekanyetso ea PQQ

Kaha pyrroloquinoline quinone (pqq) ha e so amoheloe ka botlalo ke Federal Drug Administration bakeng sa tšebeliso ea bongaka, ha ho na litekanyetso tse tloaelehileng tsa pyrroloquinoline quinone, leha lithuto tse ling li fumane hore litekanyetso tsa pyrroloquinoline quinone ho tloha 2 mg / letsatsi li na le molemo. Leha ho le joalo, boholo ba li tlatselletso tsa PQQ li litekanyetso tsa 20 ho isa ho 40 mg.

Litekanyetso tsa prinone tsa Pyrroloquinoline e ka fapana ho latela sepheo se reriloeng. Boithuto bo bong bo bonts'a hore litekanyetso tsa 0.075 ho isa ho 0.3 mg / kg ka letsatsi li sebetsa hantle ho matlafatsa ts'ebetso ea mitochondria, ha tekanyo e phahameng ea 20 mg ka letsatsi e ka ba ea hlokahala ho loana le ho ruruha.

Ha ho nkuoa hammoho le COQ10, litekanyetso tsa 20 mg PQQ le 200 mg COQ10 lia eletsoa, ​​leha lithuto tse ling tse sebelisang 20 mg ea PQQ le 300 mg COQ10 li sa ka tsa tlaleha litla-morao tse mpe.

Tlatsetso ea PQQ e lokela ho nooa ka molomo 'me ka mokhoa o loketseng pele ho lijo-ka mpeng e se nang letho.

Ka hona o eletsoa haholo ho qala ho tloha ho litekanyetso tse tlase mme o eketse ka moo ho hlokahalang.

Mme se lokelang ho hlokomeleha ke hore lithuto tse ngata ha li khothaletse ho nka tekanyetso e fetang 80 mg ka letsatsi.

Ke lijo life tse nang le pyrroloquinoline quinone (pqq)?

Pyrroloquinoline quinone (pqq) e fumanoa lijong tsa limela tse ngata, leha hangata e le ka tekanyo e tlase haholo. Limela li fumana PQQ ka kotloloho ho libaktheria tsa mobu le mobu tse kang methylotrophic, rhizobium, le libaktheria tsa acetobacter.

Pqq liseleng tsa motho e tsoa ho karolo ea lijo le karolo e itseng ho tsoa tlhahiso ea baktheria ea enteric.

Boemo ba quinine ea pyrroloquinoline mehloling ena ea lijo e fapana haholo ho tloha ho 0.19 ho isa ho la 61ng / g. Leha ho le joalo, pqq e shebane haholo le lijong tse latelang:

Pqq-Lijo

Mehloli e meng ea lijo tsa PQQ e kenyelletsa lehlaku la broccoli, mosetareta oa masimong, linaoa tsa fava, liapole, mahe, bohobe, veine le lebese.

Ka lebaka la maemo a tlase a pqq lijong tse ngata, ho tla ba thata ho fumana litefiso tse lekaneng ho tlola melemo e amanang le pqq ntle le haeba re nka lijo tse ngata haholo. Sena se hloka hore motho a reke tlatsetso ea pqq ho tlatselletsa phepelo e ntle ea phepo.

PQQ le COQ10

Coenzyme Q10 (COQ10) hangata e nkoang e le mitochondria enhancer e etsahala 'meleng oa motho le lijong tse ngata. E tšoana le PQQ; Leha ho le joalo, pyrroloquinoline quinine le CQ10 li sebetsa ka mekhoa e fapaneng haholo kapa li sebelisa mekhoa e fapaneng ho ntlafatsa mesebetsi ea mitochondrial.

Coenzyme Q10 ke cofactor ea bohlokoa e sebetsang ka har'a mitochondria mme e bapala karolo ea bohlokoa ho phefumoloheng ea sele le ts'ebeliso ea oksijene bakeng sa tlhahiso ea matla. PQQ ka lehlakoreng le leng e eketsa palo ea lisele tsa mitochondria hape e ntlafatsa ts'ebetso ea mitochondria.

Ha e kopantsoe hammoho, pyrroloquinoline quinine le CQ10, e fana ka litlamorao tsa synergetic ho ntlafatsa ts'ebetso ea mitochondrial, e re sirelletsang khatellong ea oxidative le ho laola li-pathways tsa cellular.

Reka Tlatsetso ea PQQ

Ho na le melemo e mengata e ke keng ea qojoa ea pqq supplement phofo mme o lokela ho nahana ka ho khothaletsa lijo tsa hau ka tsona. PQQ phofo ea rekisoa e fumaneha habonolo inthaneteng. Leha ho le joalo, bakeng sa litholoana tse ntle haholo u lule u falimehile haholoanyane ha u reka tlatsetso ea pqq ho netefatsa hore o fumana boleng bo holimo.

Haeba u nahana ho reka pqq bongata ba phofo netefatsa hore u e fumana ho barekisi ba tsebahalang.

References

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